Wednesday, May 17, 2017

Brief Blog: Humor: "Clone Wars" As a Metaphor in Oncology

Someone recently pointed me to an article on "Clone Wars" in oncology and the genomic evolution of tumors.

The term has some history.  That are about ten hits on PubMed specific to "Clone Wars" in oncology, and they date back to 2006.   A search for oncology + cancer + "clone wars" on Google pulls up additional hits, such as a 2013 webpage at MD Anderson (here), and a deck by ASU's George Poste (here).

For the most prominent recent article, see Beltran's article The Clone Wars in Science Translation Medicine in February 2017 (here).   For an open access example, see Worsley et al. 2016 (here).

More examples after the break.



The clone wars.
Beltran H.
Sci Transl Med. 2017 Feb 15;9(377). pii: eaam6061. doi: 10.1126/scitranslmed.aam6061.
PMID:
 
28202773
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2.
High-grade serous ovarian cancer: the clone wars.
Salomon-Perzyński A, Salomon-Perzyńska M, Michalski B, Skrzypulec-Plinta V.
Arch Gynecol Obstet. 2017 Mar;295(3):569-576. doi: 10.1007/s00404-017-4292-1. Epub 2017 Feb 3. Review.
PMID:
 
28154920
 
Free PMC Article
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3.
Clone wars: the evolution of therapeutic resistance in cancer.
Worsley CM, Mayne ES, Veale RB.
Evol Med Public Health. 2016 Jun 14;2016(1):180-1. doi: 10.1093/emph/eow015. Print 2016. No abstract available.
PMID:
 
27193201
 
Free PMC Article
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4.
Clone wars--the emergence of neoplastic blood-cell clones with aging.
Abkowitz JL.
N Engl J Med. 2014 Dec 25;371(26):2523-5. doi: 10.1056/NEJMe1412902. Epub 2014 Nov 26. No abstract available.
PMID:
 
25426835
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5.
NOTE: #5 is infectious disease not cancer.

MRSA Clone Wars: Defeating the Epidemic: Commentary on an article by Inge Skråmm, MD, PhD, et al.: "Surgical Site Infections in Orthopaedic Surgery Demonstrate Clones Similar to Those in Orthopaedic Staphylococcus aureus Nasal Carriers".
Evans RP.
J Bone Joint Surg Am. 2014 Jun 4;96(11):e95. No abstract available.
PMID:
 
24897752
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6.
Clone wars: IgH subclones in preB-ALL.
Zweidler-McKay PA.
Blood. 2012 Nov 22;120(22):4280-1. doi: 10.1182/blood-2012-09-455402. No abstract available.
PMID:
 
23175661
 
Free Article
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7.
The clone wars - revenge of the metastatic rogue state: the sarcoma paradigm.
Spraker HL, Price SL, Chaturvedi A, Schiffman JD, Jones KB, Lessnick SL, Beckerle M, Randall RL.
Front Oncol. 2012 Jan 16;2:2. doi: 10.3389/fonc.2012.00002. eCollection 2012.
PMID:
 
22649772
 
Free PMC Article
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8.
Strategizing the clone wars: pharmacological control of cellular sensitivity to radiation.
Kimple RJ.
Mol Interv. 2010 Dec;10(6):341-53. doi: 10.1124/mi.10.6.3. Review.
PMID:
 
21263160
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9.
Clone wars?
Tannert C.
EMBO Rep. 2006 Jul;7(7):656. No abstract available.
PMID:
 
16819456
 
Free PMC Article
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For a 2016 deck by ASU's George Poste citing Clone Wars, here.  For additional Poste presentations, here.